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| Millions of men all over the
world suffer from erectile dysfunction - difficulty in achieving
or maintaining penis erections.
For some, the erection problems are partial or occasional. For
others, there may be total impotence - the inability at all times to
achieve penis erections adequate for sexual intercourse.
-
Over half of all men over age 40 experience some changes in their
erectile function.
-
At age 70, two-thirds of all men have reduced erectile function.
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In the past, such sexual dysfunction was treated with injections,
surgery, and other procedures, which can be painful and embarrassing
and, worst of all, are of uncertain success. Today, there are much
better and more certain options that help men with erection
difficulties.
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Until the late 1990s, there were no truly effective oral medications for
erectile dysfunction — the inability to achieve or sustain an adequate
erection for sexual activity. The useful drugs that were available had
to be injected into the penis or inserted into the urethra.
Treatment of erectile dysfunction is much easier now, thanks to a class
of drugs called phosphodiesterase-5 (PDE-5) inhibitors. The medications
— sildenafil (Viagra), vardenafil (Levitra) and tadalafil (Cialis) — all
improve erectile function in the same basic way, but they differ in how
quickly they take effect and how long their effects last.
Viagra, Levitra and Cialis: How they work
Viagra, Levitra and Cialis prevent the breakdown of nitric oxide, a
chemical messenger that promotes relaxation and opening of the blood
vessels that supply erectile tissue in the penis. Under the influence of
nitric oxide, these vessels expand and stay dilated. Increased blood
flow makes erectile tissue swell and compress the veins that carry blood
out of the penis, resulting in a full erection.
PDE-5 inhibitors do not automatically trigger erections. Sexual
stimulation is needed to start the whole process. The medications enable
a more complete response to sexual stimulation.
Many
clinical trials have shown that PDE-5 inhibitors improve erectile
function regardless of the underlying cause or causes. Viagra, Levitra
and Cialis increase the number and quality of erections and sexual
experiences in men with erectile dysfunction due to arteriosclerosis,
diabetes, spinal cord injury, depression or the aftereffects of prostate
cancer surgery.
Similarities and differences
The
drugs have slightly different chemical compositions that affect how
quickly they work and wear off. Other distinctions — for example, which
drug may be best for men of different ages or with different medical
conditions — aren't known. No study has directly compared these three
medications.
| |
Viagra (sildenafil) |
Levitra (vardenafil) |
Cialis (tadalafil) |
| Usual Doses |
50 mg per day |
10 mg per day |
10 mg per day |
| Maximum Doses |
100 mg per day |
20 mg per day |
20 mg per day |
| Available As |
20mg, 25mg, 50mg, 100mg tablets |
2.5mg, 5mg, 10mg, 20mg tablets |
5mg, 10mg, 20mg tablets |
| How to Take |
Without Food |
Without Food |
With or Without Food |
| When to Take |
30 to 60 minutes before sexual
activity |
30 to 60 minutes before sexual
activity |
30 minutes before sexual activity |
| Duration of Effects |
Up to 4 hours |
Up to 4 hours |
24 to 36 hours |
| How Often to Use |
Up to once a day |
Up to once a day |
Up to once a day |
| Possible Side Effects |
Headache, flushing, indigestion, stuffy or runny nose, upset
stomach, diarrhea |
Headache, flushing, indigestion, stuffy or runny nose, upset
stomach, dizziness |
Headache, indigestion, back pain, muscle aches, flushing, stuffy
or runny nose |
| Warnings |
Do
not take with nitrates (Nitro-Dur, others), or if you have certain
heart valve problems. Should be used with caution or not used at
all with alpha blockers. Should not be used with some antibiotic,
antiviral or antifungal medications. |
Do
not take with nitrates (Nitro-Dur, others) or alpha blockers (Hytrin,
Cardura, others), or if you have certain heart valve problems.
Should be used with caution or not used at all with alpha
blockers. Should not be used with some antibiotic, antiviral or
antifungal medications. |
Do not take with nitrates (Nitro-Dur, others) or alpha blockers (Hytrin,
Cardura, others), or if you have certain heart valve problems.
Should be used with caution or not used at all with alpha
blockers. Should not be used with some antibiotic, antiviral or
antifungal medications. |
Several factors may affect your choice of medication, including how well
your body responds to one drug over another and how long you want the
effects of each dose to last.
Not Safe for Everyone
Although these medications can help many people, not all men can safely
take them. PDE-5 inhibitors may worsen certain medical conditions and
interact with a number of drugs. Erectile dysfunction medications are
dangerous when used with nitrate medications, such as nitroglycerin
(Nitro-Dur, others), often prescribed to prevent or treat acute angina
(chest pain due to coronary artery disease). Both types of medication
dilate blood vessels, and their combined effects can cause dizziness,
low blood pressure and loss of consciousness.
In
rare cases, men using PDE-5 inhibitors have suffered permanent, total
vision loss due to nonarteritic anterior ischemic optic neuropathy (NAION).
Because NAION and erectile dysfunction share many of the same risk
factors, it's unclear whether the drug or an underlying condition is
responsible. If you're considering an erectile dysfunction drug but have
a retinal disorder, such as diabetic retinopathy, see your eye doctor
first.
Realistic Expectations
Occasional erectile dysfunction is a common problem, particularly as men
age. Medication won't make you feel like you're 20 again, but it can
help you achieve satisfying sexual relations more often.
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This is a prescription drug used to treat male penis erection
difficulties, or erectile dysfunction (ED).
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Since it first became
available in 1998, this drug has helped about 16 million men around
the world improve their sex lives.
-
The medicine works by
increasing blood flow to the penis during sexual stimulation. It does
not cause erections directly, but enhances the response to sexual
stimulation.
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It is not a hormone or an
aphrodisiac.
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Once you take it, the drug
can work in as quickly as 30 minutes and it works for 4 hours. For
most patients, the medication can be taken as often as once a day.
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This is one of the newest FDA approved, prescription drugs for
solving penis erection difficulties (erectile dysfunction).
According to a recent news release by Bayer/GlaxoSmithKline, ninety
percent (90%) of men with erectile dysfunction reported improved
erections with the use of Levitra.
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Each pill may work in as
quickly as 25 minutes and may work for up to 24 hours.
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This drug acts in the same
way as Viagra (but is effective for longer periods), by blocking an
enzyme called phosphodiesterase-5, or PDE-5. This helps the smooth
muscles in the penis to relax, to increase blood flow and thus allow
the penis to become and stay harder longer, to maintain an erection
satisfactory for sexual intercourse.
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The product does not cause
erections directly but affects the response to sexual stimulation. It
is not an aphrodisiac or a hormone.
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The product has been
clinically shown to improve erectile function even in men who had
other health factors, like diabetes or prostate surgery.
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Men using this medication
reported having harder erections and improved overall sexual
experiences.
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A medical prescription is
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This is a FDA approved prescription drug used to treat the physical
problem of erectile dysfunction in men.
-
The active ingredient in
these tablets, tadalafil, belongs to a group of medicines called
phosphodiesterase type 5 inhibitors.
-
Following sexual
stimulation, the drug works by helping the blood vessels in your
penis to relax, allowing the flow of blood into your penis. The
result is improved male erections. It can help a majority of men,
with penis erection difficulties, to get and keep an erection when
sexually aroused.
-
The product does not cause
erections directly but affects the response to sexual stimulation.
It is not an aphrodisiac or a hormone.
-
According to clinical
studies' data on this medication (tadalafil), men with ED reported a
statistically significant improvement in successful sexual
intercourse at 36 hours after taking the drug,
compared to placebo. In Europe, where it was first launched in 2003
Cialis has been dubbed the
"weekend erections pill".
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This product is allowing
men to choose the moments when they want to have intimacy. In all
studies, compared with placebo, use of this medication demonstrated
consistent and statistically significant improvement and the
treatment effect did not diminish over time.
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Other new findings -
including a summary of cardiovascular safety data - showed no
increased incidence of cardiovascular events during clinical
studies.
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A medical prescription is
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